Tetrahydrofolate Dehydrogenase

An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.

Also Known As:

Dihydrofolate Reductase; Acid Reductase, Folic; Dehydrogenase, Dihydrofolate; Dehydrogenase, Tetrahydrofolate; Reductase, Dihydrofolate; Reductase, Folic Acid; Dihydrofolate Dehydrogenase; Folic Acid Reductase; 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on CH-NH Group Donors
      - Tetrahydrofolate Dehydrogenase: 748

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Disease

Drug/Important Bio-Agent (IBA)